منابع مشابه
The hypoglycaemic action of metformin.
Twenty-four-hour excretion of D-xylose after oral administration in nine diabetic patients, and of 3-0methyl-D-glucose in six patients, showed no significant change after treatment with metformin. There was, however, a significant reduction in mean fasting blood glucose levels in thirteen patients from 160 to 115 mg/ 100 ml (P <0001), and the intravenous glucose tolerance improved in twelve of ...
متن کاملLow Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action
Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States. The prognosis remains dismal with little advance in treatment. Metformin is a drug widely used for the treatment of type II diabetes. Recent epidemiologic data revealed that oral administration of metformin is associated with a reduced risk of pancreatic cancer, suggesting its potential as a novel drug ...
متن کاملKLF15 and metformin action Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action Running title: KLF15 and metformin action
1 Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. 2 Frontier Science Organization, Kanazawa University, Kanazawa 920-8641, Japan. 3 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, 7708503, Japan. 4 Pharmacology ...
متن کاملMetformin: from mechanisms of action to therapies.
Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular diseases and cancer. However, the underlying mechanisms of action remain elusive. Convincing data place energy metabolism at the center of metformin's mechanism of action in diabetes and may also be of im...
متن کاملMetformin raises hydrogen sulfide tissue concentrations in various mouse organs.
BACKGROUND The epidemic of diabetes mellitus type 2 forces to intensive work on the disease medication. Metformin, the most widely prescribed insulin sensitizer, exerts pleiotropic actions on different tissues by not fully recognized mechanisms. Hydrogen sulfide (H2S) is involved in physiology and pathophysiology of various systems in mammals and is perceived as a potential agent in the treatme...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2015
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2015.01.003